The Functional Maturity of Grafted Human Pluripotent Stem Cell Derived-Islets (hSC-Islets) Evaluated by the Glycemic Set Point During Blood Glucose Normalizing Process in Diabetic Mice
Scientists utilized two kinds of streptozotocin-induced diabetes model mice by changing the administration timing in order to examine the time course of maturation of hSC-islets and the effects of hyperglycemia on their maturation.
[Cell Metabolism] Using exercise and sarcopenia models, mice lacking IL6Rα on T cells demonstrated deficits in regulatory T cells, their functional maturation, and a more pronounced decline in muscle mass.
[Communications Biology] Based on the up-regulation of catabolism and down-regulation of anabolism, researchers showed genetic mutation-mediated metabolic reprogramming in the progression of cancer cachexia by screening for metabolites and investigating their direct effect on muscle atrophy.
[Acta Pharmacologica Sinica] Researchers investigated the effect of myeloid-derived growth factor to postinjury neointimal formation and the underlying mechanisms. Rat carotid arteries balloon-injured model was established.