The Inhibition of Pancreatic Cancer Progression by K-Ras-Overexpressing Mesenchymal Stem Cell-Derived Secretomes

Overexpression of K-Ras elevated PI3K signaling in MSCs, and K-Ras/PI3K-activated MSC-derived CM reduced the proliferation and migration of tumor cells, as well as the growth of ex vivo freshly isolated human PDAC cultures.