MAdCAM-1 Targeting Strategy Can Prevent Colitic Cancer Carcinogenesis and Progression via Suppression of Immune Cell Infiltration and Inflammatory Signals

Scientists evaluated the expression of mucosal addressin cell adhesion molecule-1 (MAdCAM-1), CD31, and immune cell markers in samples surgically resected from 11 ulcerative colitis patients with dysplasia/colitic cancer and 17 patients with sporadic colorectal cancer.