Nimbolide Based Nanomedicine Inhibits Cancer Stem-Like Cells by Epigenetic Reprogramming of DNMTs-SFRP1-Wnt/β-Catenin Signaling Axis in Triple-Negative Breast Cancer

The authors investigated nimbolide, a limonoid triterpenoid that has potent anticancer properties but poor pharmacokinetics and low bioavailability limit its therapeutic application.