RNF8 Ubiquitylation of XRN2 Facilitates R-loop Resolution and Restrains Genomic Instability in BRCA1 Mutant Cells

Investigators sought to identify novel targets to selectively kill BRCA1-mutant cancers. They reported that loss of RNF8 significantly protected Brca1-mutant mice against mammary tumorigenesis.
[Nucleic Acids Research]
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