α-Catenin Acetylation Is Essential for Its Stability and Blocks Its Tumor Suppressor Effects in Breast Cancer through Yap1
Researchers reported that α-catenin was acetylated by p300, and identified three acetylation sites, K45, K866, and K881. Conversely, they found that α-catenin acetylation could be reversed by deacetylase HDAC6.
[Acta Biomaterialia] Researchers demonstrated that incorporating human pancreatic decellularized extracellular matrix within alginate microcapsules resulted in a significant increase in Glucose Stimulation Index and total insulin secreted by encapsulated human islets, compared to free islets and islets encapsulated in only alginate.
[Cancer Letters] In vivo and in vitro experiments revealed that FABP4 induced macrophage-related inflammation to promote pancreatic cancer cell migration, invasion, and metastasis under obese condition.