Modeling Porcine NAFLD by Deletion of Leptin and Defining the Role of AMPK in Hepatic Fibrosis
Due to the high similarity with humans, the authors generated leptin-deficient pigs to investigate the mechanisms and clinical trials of obesity and non-alcoholic fatty liver disease (NAFLD) caused by leptin.
[Cell & Bioscience] Scientists demonstrated that CDK1 was correlated with prognosis and was highly expressed in pancreatic cancer tissue and gemcitabine-resistant cells
[Acta Biomaterialia] Researchers demonstrated that incorporating human pancreatic decellularized extracellular matrix within alginate microcapsules resulted in a significant increase in Glucose Stimulation Index and total insulin secreted by encapsulated human islets, compared to free islets and islets encapsulated in only alginate.
[Cancer Letters] In vivo and in vitro experiments revealed that FABP4 induced macrophage-related inflammation to promote pancreatic cancer cell migration, invasion, and metastasis under obese condition.