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e.g. organoids

EGFR Inhibition Overcomes Resistance to FGFR4 Inhibition and Potentiates FGFR4 Inhibitor Therapy in Hepatocellular Carcinoma

Upon the successful establishment of a battery of cellular models developing resistance to FGFR4 inhibitors, researchers identified the activation of EGFR, MAPK, and AKT signaling as the primary mechanisms mediating the acquired resistance.
[Molecular Cancer Therapeutics]
Abstract
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