In Vivo CRISPR Screen Identifies LTN1 as a Novel Tumor Suppressor Ubiquitinating Insulin–Like Growth Factor 2 mRNA–Binding Protein 1 in Hepatocellular Carcinoma
Through in vivo CRISPR knockout screens targeting related E3 ligase genes in HCC nude mice models, investigators discovered Listerin (LTN1) as a novel tumor suppressor in HCC.
[Cell & Bioscience] Scientists demonstrated that CDK1 was correlated with prognosis and was highly expressed in pancreatic cancer tissue and gemcitabine-resistant cells
[Acta Biomaterialia] Researchers demonstrated that incorporating human pancreatic decellularized extracellular matrix within alginate microcapsules resulted in a significant increase in Glucose Stimulation Index and total insulin secreted by encapsulated human islets, compared to free islets and islets encapsulated in only alginate.
[Cancer Letters] In vivo and in vitro experiments revealed that FABP4 induced macrophage-related inflammation to promote pancreatic cancer cell migration, invasion, and metastasis under obese condition.