In Vivo CRISPR Screen Identifies LTN1 as a Novel Tumor Suppressor Ubiquitinating Insulin–Like Growth Factor 2 mRNA–Binding Protein 1 in Hepatocellular Carcinoma

Through in vivo CRISPR knockout screens targeting related E3 ligase genes in HCC nude mice models, investigators discovered Listerin (LTN1) as a novel tumor suppressor in HCC.