ABCC1 and Glutathione Metabolism Limit the Efficacy of Bcl-2 Inhibitors in Acute Myeloid Leukemia

Using CRISPR/Cas9 screening, researchers found that loss of ABCC1 strongly increased the sensitivity of AML cells to Venetoclax. Genetic and pharmacologic ABCC1 inactivation potentiated the anti-leukemic effects of BCL-2 inhibitors and efficiently re-sensitized Venetoclax-resistant leukemia cells.