Synthesis and Anti-tumor Activities in Human Leukemia-Derived Cells of Polyenylpyrroles with a Methyl Group at the Conjugated Polyene Terminus

To develop novel drugs for treating T-cell acute lymphoblastic leukemia (T-ALL) and AML, a series of analogs having a polyenylpyrrole structure of natural compounds were synthesized and investigated their structure–activity relationships of in vitro anti-T-ALL and anti-AML activities.