Large Extracellular Vesicles Derived from Human Regulatory Macrophages (L-EV_Mreg) Attenuate CD3/CD28-Induced T Cell Activation In Vitro

Scientists investigated whether L-EVMreg also affect the CD3/CD28-mediated activation of T cells. Activation of human T-cells was induced by CD3/CD28-coated beads in the absence or presence of Mreg or different concentrations of L-EVMreg .