Accumulation of Endogenous Adenosine Improves Cardiomyocyte Metabolism via Epigenetic Reprogramming in an Ischemia-Reperfusion Model

Scientists investigated the role of cellular adenosine in epigenetic regulation on cardiomyocyte gene expression, glucose metabolism and tolerance to ischemia/reperfusion (I/R). Evans blue/TTC staining and echocardiography were used to assess the extent of I/R injury in mice.