miR-200a-3p Overexpression Alleviates Diabetic Cardiomyopathy Injury in Mice by Regulating Autophagy through the FOXO3/Mst1/Sirt3/AMPK Axis

Researchers used db/db mice to simulate the animal model of diabetic cardiomyopathy and the expression of miR-200a-3p was then examined by RT-qPCR. Tail vein injection of mice was done with rAAV-miR-200a-3p for eight weeks, and cardiac function was assessed by cardiac ultrasound.