Combined Inhibition of Bcl-2 Family Members and YAP Induces Synthetic Lethality in Metastatic Gastric Cancer with RASA1 and NF2 Deficiency

Investigators identified molecular drivers for metastasis and devise corresponding therapeutic strategies. They performed an unbiased in vivo genome-wide CRISPR/Cas9 knockout screening in peritoneal dissemination using genetically engineered gastric cancer mouse models.