Establishing an hTERT-Driven Immortalized Umbilical Cord-Derived Mesenchymal Stem Cell Line and Its Therapeutic Application in Mice with Liver Failure

To achieve mass production and quality control on stem cells and their exosomes, transfecting umbilical cord MSC (UCMSC) with lentivirus overexpressing human telomerase reverse transcriptase (hTERT) gene, the hTERT-UCMSC was constructed as an immortalized MSC cell line.