Chimeric Hemagglutinin Split Vaccines Elicit Broadly Cross-Reactive Antibodies and Protection Against Group 2 Influenza Viruses in Mice

Scientists showed that immunization with group 2 chimeric HA split vaccines in combination with the CpG 1018 adjuvant elicits broadly cross-reactive antibodies against all group 2 HAs, as well as systemic and local antigen-specific T cell responses.