Decellularized Human Pancreatic Extracellular Matrix-Based Physiomimetic Microenvironment for Human Islet Culture

Researchers demonstrated that incorporating human pancreatic decellularized extracellular matrix within alginate microcapsules resulted in a significant increase in Glucose Stimulation Index and total insulin secreted by encapsulated human islets, compared to free islets and islets encapsulated in only alginate.