Regulation of Epithelial Transitional States in Murine and Human Pulmonary Fibrosis

Investigators showed that human keratin (KRT) 8 genetic variants are associated with idiopathic pulmonary fibrosis. Krt8-/- mice are protected from fibrosis and accumulation of the transitional state. Keratin 8 regulated the expression of macrophage chemokines and macrophage recruitment.