CSE Reduces OTUD4 Triggering Lung Epithelial Cell Apoptosis via PAI-1 Degradation

Investigators showed that ovarian tumor family deubiquitinase 4 (OTUD4) protein reduced in CSE treated mice and airway epithelial cells. OTUD4 silence aggravated cell apoptosis and emphysematous change in the lung tissue of cigarette smoke extract (CSE) treated mice.