The Critical Role of The Piezo1/β-catenin/ATF4 Axis on The Stemness of Gli1⁺ BMSCs during Simulated Microgravity-Induced Bone Loss

By single-cell RNA sequencing, bone marrow-derived MSCs were the most downregulated cell cluster, and coincidentally, Piezo1 expression was mostly enriched in those cells, and was substantially downregulated by unloading.