Externalized Histones Fuel Pulmonary Fibrosis via a Platelet-Macrophage Circuit of TGFβ1 and Il-27

By
Laurisa Dohm
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Histones activated platelets to release TGFβ1, which signaled through the TGFbRI/TGFbRII receptor complex on LysM+ cells to antagonize macrophage-derived IL-27 production.
[Proceedings Of The National Academy Of Sciences Of The United States Of America]
Abstract