BRCC3-Mediated NLRP3 Deubiquitylation Promotes Inflammasome Activation and Atherosclerosis in Tet2 Clonal Hematopoiesis

Researchers used cholesterol-loaded Tet methylcytosine dioxygenase 2 (TET2)-deficient murine and embryonic stem cell–derived isogenic human macrophages to evaluate mechanisms of NLRP3 inflammasome activation in vitro and hypercholesterolemic Ldlr−/− mice modeling TET2 clonal hematopoiesis to assess the role of NLRP3 inflammasome activation in atherosclerosis.