A T Cell Receptor Targeting a Recurrent Driver Mutation in FLT3 Mediates Elimination of Primary Human Acute Myeloid Leukemia In Vivo

Investigators identified a T cell receptor reactive to the recurrent D835Y driver mutation in the FMS-related receptor tyrosine kinase 3 tyrosine kinase domain (TCRFLT3D/Y). TCRFLT3D/Y-redirected T cells selectively eliminated primary human AML cells harboring the FLT3D835Y mutation in vitro and in vivo.