Direct Regulation of FNIP1 and FNIP2 by MEF2 Sustains MTORC1 Activation and Tumor Progression in Pancreatic Cancer

The authors demonstrated that transcription factors myocyte enhancer factor 2A (MEF2A) and MEF2D synergistically regulated mechanistic target of rapamycin kinase complex 1 (MTORC1) activation via modulating its cyto-lysosome shutting.