Deletion of the Inhibitory Co-receptor CTLA4 Enhances and Invigorates Chimeric Antigen Receptor T Cells

Scientists investigated whether disruption of the co-inhibitory receptors CTLA4 or PD-1 could restore CART function. CRISPR-Cas9-mediated deletion of CTLA4 in preclinical models of leukemia and myeloma improved CAR T cell proliferation and anti-tumor efficacy.