Bioactive and Chemically Defined Hydrogels with Tunable Stiffness Guide Cerebral Organoid Formation and Modulate Multi-Omics Plasticity in Cerebral Organoids

Using cerebral organoids (COs) as exemplar, researchers demonstrated the possibility to create bio-instructive hydrogels with tunable stiffness ranging from 0.69 kPa to 2.24 kPa to culture and induce COs growth.