Targeting LINC01607 Sensitizes Hepatocellular Carcinoma to Lenvatinib via Suppressing Mitophagy

Researchers identified inhibition of reactive oxygen species levels and reduced redox status in Lenvatinib-resistant HCC. Integrating RNA-seq with unbiased whole-genome CRISPR-Cas9 screen analysis indicated LINC01607 regulated the P62 to enhance drug resistance by affecting mitophagy and antioxidant pathways.