Single-Cell Profiling and Zebrafish Avatars Reveal LGALS1 As Immunomodulating Target in Glioblastoma

Scientists used patient-derived glioblastoma (GBM) stem cell cultures and combined single-cell RNA sequencing of GBM-associated macrophages (GAM)-GBM co-cultures and real-time in vivo monitoring of GAM-GBM interactions in orthotopic zebrafish xenograft models to provide insight into the cellular, molecular, and spatial heterogeneity.