DDX5 (p68) Orchestrates β-Catenin, RelA and SP1 Mediated MGMT Gene Expression in Human Colon Cancer Cells: Implication in TMZ Chemoresistance

Investigators uncovered an unidentified mechanism of DDX5-mediated MGMT gene regulation. Experimentally, they found that both mRNA and protein expression levels of MGMT were elevated in response to p68 overexpression in multiple human colon cancer cell lines and vice-versa.