Stabilization of Cx43 mRNA via RNA-Binding Protein HuR Regulated by Polyamines Enhances Intestinal Epithelial Barrier Function

Scientists showed that HuR is directly bound to connexin 43 (Cx43) mRNA via its 3′-untranslated region in intestinal epithelial cells and this interaction enhanced Cx43 expression by stabilizing Cx43 mRNA.