Control of the Antitumour Activity and Specificity of CAR T Cells via Organic Adapters Covalently Tethering the CAR to Tumour Cells

Scientists showed that the tumor-targeting specificity and activity of T cells with a CAR consisting of an antibody with a lysine residue that catalytically formed a reversible covalent bond with a 1,3-diketone hapten can be regulated by the concentration of a small-molecule adapter.