Newsletters

[Keck School of Medicine of USC] A $2.1 million grant from CIRM supports the new project designed to understand how mature lab-grown kidney structures, which combine the kidney’s filtering and urine-collecting components, can improve the study of disease and development of therapies.

[Cell Stem Cell] Investigators used human endometrial organoids to establish an in vitro menstrual cycle protocol that recapitulates cyclical epithelial dynamics.

[ACS Applied Materials & Interfaces] Researchers introduced PEDOT-coated printed circuit board electrodes as a biosensing platform for low-noise recording of organoid electrical activity.

[Journal of Nanobiotechnology] Scientists developed a robust differentiation protocol to derive distal respiratory airway organoids from hPSCs and investigated their role in the treatment of chronic obstructive pulmonary disease.

[Stem Cell Reviews and Reports] Investigators determined whether retinal organoids exhibit an accessory inner segment-like structure, to support future in vitro studies of its role in photoreceptor structure and disease.

[Molecular Cancer] The authors summarize the multidimensional applications of organoids in translational cancer therapy, critically discuss their advantages and current limitations, and outline key directions for future development.

[Nature Reviews Bioengineering] Scientists explore the diverse applications of human organoids in investigating organ-specific infections and disease manifestations across major physiological systems with a primary emphasis on viral pathogens.

[Microsystems & Nanoengineering] The authors review highlights recent progress in biomimetic platforms that more faithfully recapitulate the structure and function of the human myocardium, including engineered three-dimensional tissues, chambered ventricular constructs, self-organizing cardiac organoids, and microphysiological systems.

[UMass Chan Medical School] Dr. Marcus Ruscetti, is one of 13 investigators to receive the prestigious 2026 Pershing Square Sohn Cancer Prize from the Pershing Square Sohn Cancer Research Alliance. Dr. Ruscetti will study how cells in the liver experiencing senescence create an immune-suppressive environment that enables pancreatic cancer metastasis.

[OICR] Four new research studies funded by the Ontario Institute for Cancer Research (OICR) will deliver innovations by maximizing the impact of existing research and making the most out of patient contributions. OICR is supporting the studies through CATALYST, a new funding stream for research that leverages available patient data and donated samples to advance new insights about detecting, diagnosing and treating cancer.

[British Journal of Cancer] Scientists conducted an integrated analysis of RNA sequencing data using established chemoresistant colorectal cancer (CRC) cell lines and publicly available single-cell transcriptomic datasets of clinical CRC samples to clarify the underlying mechanisms associated with acquired chemoresistance.

[Nature Cell Biology] Investigators showed a microwell cell-chip culture platform that enabled rapid, high-throughput generation of uniform micro-tumourspheres from limited breast cancer specimens, such as puncture biopsies, facilitating functional CSC enrichment and personalized drug testing within eight days.