STING Activation in TET2-Mutated Hematopoietic Stem/Progenitor Cells Contributes to the Increased Self-Renewal and Neoplastic Transformation

Researchers showed that the cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-stimulator of interferon genes (STING) pathway was activated to mediate the effect of Ten-eleven translocation-2 (TET2) deficiency in dysregulated hematopoiesis in mouse models.