Pineal Gland Hormone Melatonin Inhibits Migration of Hematopoietic Stem/Progenitor Cells (HSPCs) by Downregulating Nlrp3 Inflammasome and Upregulating Heme Oxygenase-1 (HO-1) Activity

Researchers provided evidence that melatonin being a ‘’sleep regulating pineal hormone’’ directly inhibited migration of hematopoiesis stem and progenitor cells both in vitro migration assays and in vivo during pharmacological mobilization.