Modeling of Intramembranous Ossification Using Human Pluripotent Stem Cell-Derived Paraxial Mesoderm Derivatives

Scientists developed a human PSC-based system that models the human intramembranous ossification process. They found that spheroid culture of the hPSC-derived paraxial mesoderm derivatives generated osteoprogenitors or osteo-chondroprogenitors depending on stimuli.