PRIMA-1 Synergizes Olaparib-Induced Cell Death in p53 Mutant Triple Negative Human Breast Cancer Cell Line via Restoring p53 Function, Arresting Cell Cycle, and Inducing Apoptosis

Scientists assessed the effect of restoring p53 using PRIMA-1 on the anti-cancer activity of olaparib against TP53-mutant TNBC cells and explored the optimum synergistic concentrations and the underlying mechanism.