Synthetic Augmentation of Bilirubin Metabolism in Human Pluripotent Stem Cell-Derived Liver Organoids

Researchers used iPSCs to develop human liver organoids that can emulate conjugation failure phenotype. Bilirubin conjugation assays, chromatin immunoprecipitation, and transcriptome analysis elucidated the role of glucocorticoid antagonism in UDP glucuronosyltransferase family 1 member A1 activation.