Card9/Neutrophil Signaling Axis Promotes IL-17A-Mediated Ankylosing Spondylitis

Experiments in SKG, Card9−/−SKG, neutrophil-deplete SKG mice along with in vitro murine, neutrophil and CD4+ T cell cocultures examined Card9 function in neutrophil activation, Th17 induction and arthritis in experimental ankylosing spondylitis.