Progenitor-Like Exhausted SPRY1⁺CD8⁺ T Cells Potentiate Responsiveness to Neoadjuvant PD-1 Blockade in Esophageal Squamous Cell Carcinoma

Researchers performed single-cell RNA-sequencing of tumors from patients with esophageal squamous cell carcinoma undergoing neoadjuvant immune checkpoint blockade, revealing a subset of exhausted CD8+ T cells expressing SPRY1 that displayed a progenitor exhausted T cell phenotype.