Impact of Human Recombinant Irisin on Tissue-Engineered Skeletal Muscle Structure and Function

Investigators determined the impact of human recombinant irisin on the growth and development of three-dimensional engineered skeletal muscle. Muscle satellite cells were cultured without irisin, or with either 50 ng/ml, 100 ng/ml, or 250 ng/ml of irisin supplementation.