Engineered Heart Tissue Maturation Inhibits Cardiomyocyte Proliferative Response to Cryoinjury

Considering the lack of reliable in vitro tissue-like models to evaluate the molecular mechanisms of cardiac regeneration, scientists used cryoinjury on rat Engineered Heart Tissues as a new model which recapitulated in part the in vivo response after myocardial injury of neonatal and adult heart.