The Role of Aplnr Signaling in the Developmental Regulation of Mesenchymal Stem Cell Differentiation from Human Pluripotent Stem Cells

Scientists unveiled the role of apelin receptor signaling during mesoderm and MSC differentiation from pluripotent stem cells through peptide/small molecule activation, overexpression, knock down or CRISPR/Cas9 mediated knock out of the pathway components.