Zfp335 Establishes eTreg Lineage and Neonatal Immune Tolerance by Targeting Hadha-Mediated Fatty Acid Oxidation

Scientists showed that Zfp335 deletion in Tregs failed to differentiate into effector Tregs (eTregs) and lost Treg-suppressive function, and that KO mice exhibited early-onset lethal autoimmune inflammation with unrestricted activation of conventional T cells.