PI3K/mTOR Inhibitors Promote G6PD Autophagic Degradation and Exacerbate Oxidative Stress Damage to Radiosensitize Small Cell Lung Cancer

Researchers explored the metabolic rewiring behind radioresistance and found therapeutic approaches to overcome radioresistance. Pharmacological inhibition of PI3K/AKT/mTOR signaling improved the effectiveness of radiotherapy, including inhibiting cell proliferation, increasing cell apoptosis, and suppressing cell migration.