Collagen 1-Mediated CXCL1 Secretion in Tumor Cells Activates Fibroblasts to Promote Radioresistance of Esophageal Cancer

Using RNA sequencing, cytokine arrays, and single-cell RNA sequencing, investigators revealed an enrichment of cancer-associated fibroblast-derived collagen type 1 and tumor-cell-derived CXCL1 in non-responsive patient-derived xenografts.