The Bone Mesenchymal Stem Cell-Derived Exosomal miR-146a-5p Promotes Diabetic Wound Healing in Mice via Macrophage M1/M2 Polarization

Researchers extracted bone marrow mesenchymal stem cell (BMSC)-derived exosomes (EXO). Electroporation technology was used to load miR-146a-5p into EXO. Human umbilical vein endothelial cells HUVECs and macrophages were cocultured in transwell chambers in the presence of high glucose. Cell proliferation, migration, and angiogenesis were measured with cell counting kit 8, scratch, and tube forming assays, respectively.