CD226 Maintains Regulatory T Cell Phenotype Stability and Metabolism by the mTOR/Myc Pathway under Inflammatory Conditions

Conditional deletion of CD226 within Foxp3+ cells exacerbated symptoms in murine graft versus host disease models, and Treg cell-specific deletion of CD226 increased the Treg cell percentage in immune organs but weakened their immunosuppressive function with a T helper 1-like phenotype conversion under inflammation.