A Gain-of-Function p53 Mutant Synergizes with Oncogenic NRAS to Promote Acute Myeloid Leukemia in Mice

The authors reported that in contrast to mixed AML and T cell malignancy developed in NrasG12D/+; p53-/- mice, NrasG12D/+; p53R172H/+ mice rapidly developed an inflammation-associated AML.