Sohlh2 Promotes Pulmonary Fibrosis via Repression of p62/Keap1/Nrf2 Mediated Anti-Oxidative Signaling Pathway

Using a type II alveolar epithelial cell-specific Sohlh2 conditional knock-in mouse model, researchers found that Sohlh2, a basic HLH transcription factor, accelerated age-related pulmonary fibrosis.